InBase, Intein Alleles - Inteins Sorted by Extein Insertion Site

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InBase, The Intein Database:

Intein Alleles - Inteins Sorted by Extein Insertion Site

InBase Reference: Perler, F. B. (2002). InBase, the Intein Database. Nucleic Acids Res. 30, 383-384.

Perler 1997 suggested that intein homologs present at the same insertion site in homologous extein genes should be considered intein alleles.

It is interesting to note that M. leprae and M. tuberculosis have inteins in pps1, recA and dnaB genes, but in each case, the insertion site is at a different location in the extein. In fact, many extein genes have unrelated inteins inserted at different positions.

Intein allele groups listed below:

CDC21, Cell division control protein 21 (CDC21-a insertion site) (6 inteins)

CDC21, Cell division control protein 21 (CDC21-b insertion site) (5 inteins)

CDC21, Cell division control protein 21 (CDC21-c insertion site) (5 inteins)

DNA Polymerase A (dpol-b insertion site) (3 inteins)

DNA polymerase I Motif A (pol-a insertion site) (5 inteins)

DNA polymerase I Motif B (pol-b insertion site) (17 inteins)

DNA polymerase I Motif C (pol-c insertion site) (13 inteins)

DNA polymerase II, DP2 subunit (pol II-a insertion site) (8 inteins)

DnaB helicase (dnaB-a insertion site) (19 inteins)

DnaB helicase (dnaB-b insertion site) (25 inteins)

DnaB helicase (dnaB-c insertion site) (3 inteins)

DnaE (dnaE-a insertion site) (28 inteins)

DnaE (dnaE-b insertion site) (3 inteins)

DnaE (dnaE-c insertion site) (3 inteins)

Filamentous hemagglutinin (fha-a insertion site) (3 inteins)

Glutamate synthase (GLT1-a insertion site) (5 inteins)

Gyrase subunit B (gyrB-a insertion site) (3 inteins)

Gyrase subunit A (gyrA-a insertion site) (11 inteins)

Helicase (helicase-a insertion site) (3 inteins)

Helicase (helicase-b insertion site) (3 inteins)

Helicase- Primase (primase-a insertion site) (3 inteins)

IF2, Translation initiation factor (IF2-a insertion site) (7 inteins)

KlbA (klbA-a insertion site) (5 inteins)

Large helicase related protein (LHR-a insertion site) (2 inteins)

Lon, ATP-dependent protease LA (lon-a insertion site) (3 inteins)

Mja rPol A'' (rPol A''-a insertion site) (3 inteins)

MP-Be gp51 (MP-Be_gp51-a insertion site) (2 inteins)

MupF (mupF-a insertion site) (2 inteins)

Phosphoenolpyruvate synthase (PEPsyn-a insertion site) (2 inteins)

PRP8, pre-mRNA splicing factor (PRP8-a insertion site) (32 inteins)

r-Gyr and TopA conserved topoisomerase domain (top-a insertion site) (5 inteins)

RecA (recA-a insertion site) (3 inteins)

RecA (recA-b insertion site) (9 inteins)

RecA (recA-c insertion site) (3 inteins)

Replication factor C (RFC-a insertion site) (6 inteins)

Replication factor C (RFC-b insertion site) (2 inteins)

Replication factor C (RFC-c insertion site) (2 inteins)

Ribonucleoside Triphosphate Reductase (RIR1-d insertion site) (2 inteins)

Ribonucleoside-diphosphate reductase (RIR1-a insertion site) (3 inteins)

Ribonucleoside-diphosphate reductase (RIR1-b insertion site) (30 inteins)

Ribonucleoside-diphosphate reductase (RIR1-e insertion site) (3 inteins)

Ribonucleoside-diphosphate reductase (RIR1-g insertion site) (2 inteins)

Ribonucleoside-diphosphate reductase (RIR1-i insertion site) (10 inteins)

Ribonucleoside-diphosphate reductase (RIR1-j insertion site) (3 inteins)

Ribonucleotide reductase, Anaerobic (RNR-b insertion site) (2 inteins)

Ribonucleotide reductase, Anaerobic (RNR-c insertion site) (2 inteins)

RNA polymerase II, RPB2 (RPB2-b insertion site) (3 inteins)

RNA polymerase II, RPB2 (RPB2-c insertion site) (2 inteins)

RNA terminal phosphate cyclase operon orfB (rtcB-a insertion site) (6 inteins)

Snf2 helicase/Rad54 -related protein, (snf2-a insertion site) (5 inteins)

SufB FeS assembly protein, formerly Pps1 (SufB-b inseriton site) (5 inteins)

Threonyl-tRNA synthetase (thrRS-a insertion site) (2 inteins)

UDP-glucose 6-dehydrogenase (UDP_GD-a insertion site) (2 inteins)

Vacuolar ATPase / H+-transporting ATP synthase (VMA-a insertion site) (27 inteins)

Vacuolar ATPase / H+-transporting ATP synthase (VMA-b insertion site) (7 inteins)

Inteins grouped by insertion site in the extein gene

Intein Name	Class	Extein	Prototype Allele	Organism

CDC21, Cell division control protein 21 (CDC21-a insertion site)
Hma CDC21	Theo.	Cell division control protein 21	Pho CDC21-1	Haloarcula marismortui ATCC 43049
Hsa-NRC1 CDC21	Theo.	Cell division control protein 21	Pho CDC21-1	Halobacterium salinarum NRC-1
Hwa MCM-1	Theo.	ATP-dependent DNA helicase, CDC	Pho CDC21-1	Haloquadratum walsbyi DSM 16790
Nph CDC21	Theo.	Cell division control protein 21, ATP-dependent DNA helicase	Pho CDC21-1	Natronomonas pharaonis DSM 2160
Pab CDC21-1	Theo.	Cell division control protein 21	Pho CDC21-1	Pyrococcus abyssi
Pho CDC21-1	Theo.	Cell division control protein 21	Pho CDC21-1	Pyrococcus horikoshii OT3

CDC21, Cell division control protein 21 (CDC21-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hwa MCM-2	Theo.	ATP-dependent DNA helicase, CDC	Pho CDC21-2	Haloquadratum walsbyi DSM 16790
Pab CDC21-2	Theo.	Cell division control protein 21	Pho CDC21-2	Pyrococcus abyssi
Pfu CDC21	Theo.	Cell division control protein 21	Pho CDC21-2	Pyrococcus furiosus
Pho CDC21-2	Theo.	Cell division control protein 21	Pho CDC21-2	Pyrococcus horikoshii OT3
Tko CDC21-1	Theo.	Cell division control protein 21	Pho CDC21-2	Thermococcus kodakaraensis KOD1

CDC21, Cell division control protein 21 (CDC21-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hwa MCM-4	Theo.	ATP-dependent DNA helicase, CDC	Tko CDC21-2	Haloquadratum walsbyi DSM 16790
Memar MCM2	Theo.	MCM2, ATPase involved in replication control, Cdc46/Mcm family	Tko CDC21-2	Methanoculleus marisnigri JR1
Smar MCM2	Theo.	MCM2, ATPase involved in replication control, Cdc46/Mcm family	Tko CDC21-2	Staphylothermus marinus F1
Tko CDC21-2	Theo.	Cell division control protein 21	Tko CDC21-2	Thermococcus kodakaraensis KOD1
Unc-MetRFS MCM2	Theo.	MCM2, ATPase involved in replication control, Cdc46/Mcm family	Tko CDC21-2	uncultured archaeon (Rice Cluster I)

DNA Polymerase A (dpol-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
SaP-SETP12 dpol	Theo.	DNA polymerase A	SaP-SETP3 dpol	Salmonella phage SETP12
SaP-SETP3 dpol	Theo.	DNA polymerase A	SaP-SETP3 dpol	Salmonella phage SETP3
SaP-SETP5 dpol	Theo.	DNA polymerase A	SaP-SETP3 dpol	Salmonella phage SETP5

DNA polymerase I Motif A (pol-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mja Pol-1	Theo.	DNA polymerase v	Pko Pol-1	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Nph PolB-1	Theo.	DNA-directed DNA polymerase (family B)	Pko Pol-1	Natronomonas pharaonis DSM 2160
Tag Pol-1 (Tsp-TY Pol-1)	Exp.	DNA polymerase (alpha or type-B family)	Pko Pol-1	Thermococcus aggregans
Tfu Pol-1	Exp.	DNA polymerase (alpha or type-B family)	Pko Pol-1	Thermococcus fumicolans
Tko Pol-1 (Pko Pol-1)	Exp.	DNA polymerase (alpha or type-B family)	Pko Pol-1	Pyrococcus/ Thermococcus kodakaraensis KOD1

DNA polymerase I Motif B (pol-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hma PolB	Theo.	DNA polymerase B elongation subunit	Tli Pol-1	Haloarcula marismortui ATCC 43049
Hwa PolB-2	Theo.	DNA polymerase B (alpha or type-B family)	Tli Pol-1	Haloquadratum walsbyi DSM 16790
Mja Pol-2	Theo.	DNA polymerase v	Tli Pol-1	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Nph PolB-2	Theo.	DNA-directed DNA polymerase (family B)	Tli Pol-1	Natronomonas pharaonis DSM 2160
Pho Pol I	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Pyrococcus horikoshii OT3
Psp-GBD Pol	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Pyrococcus species GB-D
Sru PolBc	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Salinibacter ruber DSM 13855
Tag Pol-2 (Tsp-TY Pol-2)	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus aggregans
Thy Pol-1	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus hydrothermalis
Tko Pol-2 (Pko Pol-2)	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Pyrococcus/Thermococcus kodakaraensis KOD1
Tli Pol-1	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus litoralis
Ton-NA1 Pol	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus onnurineus NA1
Tsp-GE8 Pol-1	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus species GE8
Tsp-GT Pol-1	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus species GT
Tsp-OGL-20P Pol	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus sp. OGL-20P
Tthi Pol	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus thioreducens
Tzi Pol	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-1	Thermococcus zilligii

DNA polymerase I Motif C (pol-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
APMV Pol	Theo.	DNA polymerase B (alpha or type-B family)	Tli Pol-2	Acanthomoeba polyphaga Mimivirus
HaV01 Pol	Theo.	DNA polymerase B (alpha or type-B family)	Tli Pol-2	Heterosigma akashiwo virus 01
Hvo PolB	Theo.	DNA polymerase B (alpha or type-B family)	Tli Pol-2	Haloferax volcanii DS70
Hwa PolB-3	Theo.	DNA polymerase B (alpha or type-B family)	Tli Pol-2	Haloquadratum walsbyi DSM 16790
Neq Pol-c	Exp.	DNA polymerase (alpha family)	Tli Pol-2	Nanoarchaeum equitans Kin4-M
Neq Pol-n	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-2	Nanoarchaeum equitans Kin4-M
Tag Pol-3 (Tsp-TY Pol-3)	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-2	Thermococcus aggregans
Tfu Pol-2	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-2	Thermococcus fumicolans
Thy Pol-2	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-2	Thermococcus hydrothermalis
Tli Pol-2	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-2	Thermococcus litoralis
Tpe Pol	Theo.	DNA polymerase B (alpha or type-B family)	Tli Pol-2	Thermococcus peptonophilus strain SM2
Tsp-GE8 Pol-2	Exp.	DNA polymerase (alpha or type-B family)	Tli Pol-2	Thermococcus species GE8
Tsp-GT Pol-2	Theo.	DNA polymerase (alpha or type-B family)	Tli Pol-2	Thermococcus species GT

DNA polymerase II, DP2 subunit (pol II-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hma Pol-II	Theo.	DNA polymerase II, DP2 subunit	Pho Pol-II	Haloarcula marismortui ATCC 43049
Hsa-NRC1 Pol-II	Theo.	DNA polymerase II, DP2 subunit	Pho Pol-II	Halobacterium salinarum NRC-1
Hwa Pol-II-1	Theo.	DNA polymerase II, DP2 subunit	Pho Pol-II	Haloquadratum walsbyi DSM 16790
Memar Pol-II	Theo.	DNA polymerase II, DP2 subunit, PolC_DP2	Pho Pol-II	Methanoculleus marisnigri JR1
Mhu Pol-II	Theo.	DNA polymerase II, DP2 subunit	Pho Pol-II	Methanospirillum hungateii JF-1
Pab Pol-II	Exp.	DNA polymerase II, DP2 subunit	Pho Pol-II	Pyrococcus abyssi
Pho Pol-II	Theo.	DNA polymerase II, DP2 subunit	Pho Pol-II	Pyrococcus horikoshii OT3
Tko Pol-II	Theo.	DNA polymerase II, DP2 subunit	Pho Pol-II	Thermococcus kodakaraensis KOD1

DnaB helicase (dnaB-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Gth DnaB	Theo.	DnaB helicase	Ssp DnaB	Guillardia theta (plastid)
Kra DnaB	Theo.	DnaB helicase	Ssp DnaB	Kineococcus radiotolerans SRS30216
Mbo-1173P DnaB	Theo.	DnaB helicase	Ssp DnaB	Mycobacterium bovis BCG Pasteur 1173P
Mbo-AF2122 DnaB	Theo.	DnaB helicase	Ssp DnaB	Mycobacterium bovis subsp. bovis AF2122/97
Msm DnaB-2	Theo.	DnaB helicase	Ssp DnaB	Mycobacterium smegmatis MC2 155
Mtu-CDC1551 DnaB	Exp.	DnaB helicase	Ssp DnaB	Mycobacterium tuberculosis, CDC1551
Mtu-F11 DnaB	Theo.	DnaB helicase	Ssp DnaB	Mycobacterium tuberculosis, strain F11
Mtu-H37Ra DnaB	Theo.	DnaB helicase	Ssp DnaB	Mycobacterium tuberculosis H37Ra
Mtu-H37Rv DnaB	Exp.	DnaB helicase	Ssp DnaB	Mycobacterium tuberculosis H37Rv
Nfa DnaB	Theo.	DnaB helicase	Ssp DnaB	Nocardia farcinica IFM 10152
Npu DnaB	Theo.	DnaB helicase	Ssp DnaB	Nostoc punctiforme
Nsp-PCC7120 DnaB	Theo.	DnaB helicase	Ssp DnaB	Nostoc species PCC7120, (Anabaena sp. PCC7120)
Ppu DnaB	Theo.	DnaB helicase	Ssp DnaB	Porphyra purpurea (chloroplast)
Pye DnaB	Theo.	DnaB helicase	Ssp DnaB	Porphyra yezoensis chloroplast, cultivar U-51
Rma DnaB	Exp.	DnaB helicase	Ssp DnaB	Rhodothermus marinus
Ssp DnaB	Exp.	DnaB helicase	Ssp DnaB	Synechocystis species, strain PCC6803
Ssp-JA2 DnaB	Theo.	DnaB helicase	Ssp DnaB	Synechococcus species JA-2-3B'a(2-13)
Ssp-JA3 DnaB	Theo.	DnaB helicase	Ssp DnaB	Synechococcus species JA-3-3Ab
Ter DnaB-2	Theo.	DnaB helicase	Ssp DnaB	Trichodesmium erythraeum IMS101

DnaB helicase (dnaB-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Aeh DnaB-1	Theo.	DnaB Helicase	Mle DnaB	Alkalilimnicola ehrlichei MLHE-1
Bce DnaB	Theo.	DnaB helicase	Mle DnaB	Burkholderia cenocepacia PC184
Cwa DnaB	Theo.	DnaB helicase	Mle DnaB	Crocosphaera watsonii WH 8501 (Synechocystis sp. WH 8501)
Dge DnaB	Theo.	DnaB helicase	Mle DnaB	Deinococcus geothermalis DSM11300
Fal DnaB	Theo.	DnaB helicase	Mle DnaB	Frankia alni ACN14a
Gvi DnaB	Theo.	DnaB helicase	Mle DnaB	Gloeobacter violaceus, PCC 7421
Hhal DnaB-1	Theo.	DnaB helicase	Mle DnaB	Halorhodospira halophila SL1
Mav DnaB	Exp.	DnaB helicase	Mle DnaB	Mycobacterium avium
Mav-104 DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium avium 104
Mav-PT DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium avium subsp. paratuberculosis str. k10
Mfl-PYR-GCK DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium flavescens PYR-GCK
Mgi-PYR-GCK DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium gilvum PYR-GCK
Min DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium intracellulare
Mle DnaB	Exp.	DnaB helicase	Mle DnaB	Mycobacterium leprae, strain TN
Msm DnaB-1	Theo.	DnaB helicase	Mle DnaB	Mycobacterium smegmatis MC2 155
Msp-KMS DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium species KMS
Msp-MCS DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium species MCS
Mvan DnaB	Theo.	DnaB helicase	Mle DnaB	Mycobacterium vanbaalenii PYR-1
Nsp-JS614 DnaB	Theo.	DnaB helicase	Mle DnaB	Nocardioides species JS614
PP-PhiEL Helicase	Theo.	Helicase, PhiEL_ORF166	Mle DnaB	Pseudomonas aeruginosa phage phiEL
Pnuc DnaB	Theo.	DnaB helicase	Mle DnaB	Polynucleobacter sp. QLW-P1DMWA-1
Posp-JS666 DnaB	Theo.	DnaB helicase	Mle DnaB	Polaromonas species JS666
Sru DnaB	Theo.	DnaB helicase	Mle DnaB	Salinibacter ruber DSM 13855
Susp-NBC371 DnaB intein	Theo.	DnaB helicase	Mle DnaB	Sulfurovum sp. NBC37-1
Ter DnaB-1	Exp.	DnaB helicase	Mle DnaB	Trichodesmium erythraeum IMS101

DnaB helicase (dnaB-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Aeh DnaB-2	Theo.	DnaB helicase	Cbu DnaB	Alkalilimnicola ehrlichei MLHE-1
Cbu DnaB	Theo.	DnaB helicase	Cbu DnaB	Coxiella burnetii RSA 493
Hhal DnaB-2	Theo.	DnaB helicase	Cbu DnaB	Halorhodospira halophila SL1

DnaE (dnaE-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Aha DnaE-c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Aphanothece halophytica
Aha DnaE-n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Aphanothece halophytica
Aov DnaE-c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Aphanizomenon ovalisporum
Aov DnaE-n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Aphanizomenon ovalisporum
Asp DnaE-c	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Anabaena species PCC7120, (Nostoc sp. PCC7120)
Asp DnaE-n	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Anabaena species PCC7120, (Nostoc sp. PCC7120)
Ava DnaE-c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Anabaena variabilis ATCC29413
Ava DnaE-n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Anabaena variabilis ATCC29413
Cwa DnaE-c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Crocosphaera watsonii WH 8501 (Synechocystis sp. WH 8501)
Cwa DnaE-n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Crocosphaera watsonii WH 8501 (Synechocystis sp. WH 8501)
Npu DnaE-c	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Nostoc punctiforme PCC73102
Npu DnaE-n	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Nostoc punctiforme PCC 73102
Nsp-PCC7120 DnaE-c	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Nostoc species PCC7120, (Anabaena sp. PCC7120)
Nsp-PCC7120 DnaE-n	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Nostoc species PCC7120, (Anabaena sp. PCC7120)
Oli DnaE-c	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Oscillatoria limnetica str. 'Solar Lake'
Oli DnaE-n	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Oscillatoria limnetica str. 'Solar Lake'
Sel-PC7942 DnaE-c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Synechococcus elongatus PC7942
Sel-PC7942 DnaE-n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Synechococcus elongatus PC7942
Sel-PCC6301 DnaE-c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Synechococcus elongatus PCC 6301 and PCC7942
Sel-PCC6301 DnaE-n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Synechococcus elongatus PCC 6301
Ssp DnaE-c	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Synechocystis species, strain PCC6803
Ssp DnaE-n	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Synechocystis species, strain PCC6803
Tel DnaE-c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Thermosynechococcus elongatus BP-1
Tel DnaE-n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Thermosynechococcus elongatus BP-1
Ter DnaE-3c	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Trichodesmium erythraeum IMS101
Ter DnaE-3n	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Trichodesmium erythraeum IMS101
Tvu DnaE-c	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-c	Thermosynechococcus vulcanus
Tvu DnaE-n	Exp.	DnaE pol subunit, DNA polymerase III alpha subunit	Ssp DnaE-n	Thermosynechococcus vulcanus

DnaE (dnaE-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Ter DnaE-2	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ter DnaE-2	Trichodesmium erythraeum IMS101
Tth-HB27 DnaE-1	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ter DnaE-2	Thermus thermophilus HB27
Tth-HB8 DnaE-1	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Ter DnaE-2	Thermus thermophilus HB8

DnaE (dnaE-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Gob DnaE	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Tth-HB8-2 DnaE	Gemmata obscuriglobus UQM2246
Tth-HB27 DnaE-2	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Tth-HB8 DnaE-2	Thermus thermophilus HB27
Tth-HB8 DnaE-2	Theo.	DnaE pol subunit, DNA polymerase III alpha subunit	Tth-HB8 DnaE-2	Thermus thermophilus HB8

Filamentous hemagglutinin (fha-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Pfl Fha BIL	Theo.	Filamentous hemagglutinin	Psy Fha	Pseudomonas fluorescens Pf-5
Pssp-A1-1 Fha	Theo.	Filamentous hemagglutinin	Psy Fha	Pseudomonas species A1-1
Psy Fha	Theo.	Filamentous hemagglutinin	Psy Fha	Pseudomonas syringae pv. tomato str. DC3000

Glutamate synthase (GLT1-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Dhan GLT1	Theo.	Glutamate synthase	Dhan GLT1	Debaryomyces hansenii CBS767
Pan GLT1	Theo.	Glutamate synthase (NADPH-GOGAT)	Dhan GLT1	Podospora anserina
Pgu GLT1	Theo.	Glutamate synthase (NADPH-GOGAT)	Dhan GLT1	Pichia (Candida) guilliermondii
Pgu-alt GLT1	Theo.	Glutamate synthase, alt. code 12	Dhan GLT1	Pichia (Candida) guilliermondii
Pno GLT1	Theo.	Glutamate synthase	Dhan GLT1	Phaeosphaeria nodorum SN15

Gyrase subunit B (gyrB-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hwa GyrB	Theo.	DNA gyrase subunit B	Ssp Gyr	Haloquadratum walsbyi DSM 16790
Ssp GyrB	Theo.	DNA gyrase subunit B	Ssp GyrB	Synechocystis species, strain PCC6803
Ter GyrB	Theo.	DNA gyrase subunit B	Ssp GyrB	Trichodesmium erythraeum IMS101

Gyrase subunit A (gyrA-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mfl GyrA	Exp.	DNA gyrase subunit A	Mle GyrA	Mycobacterium flavescens Fla0
Mga GyrA	Theo.	DNA gyrase subunit A	Mle GyrA	Mycobacterium gastri
Mgi-PYR-GCK GyrA	Theo.	DNA gyrase subunit A	Mle GyrA	Mycobacterium gilvum PYR-GCK
Mgo GyrA	Exp.	DNA gyrase subunit A	Mle GyrA	Mycobacterium gordonae
Mkas GyrA	Exp.	DNA gyrase subunit A	Mle GyrA	Mycobacterium kansasii
Mle GyrA	Exp.	DNA gyrase subunit A	Mle GyrA	Mycobacterium leprae TN
Mma GyrA	Exp.	DNA gyrase subunit A	Mle GyrA	Mycobacterium malmoense
Msp-KMS GyrA	Theo.	DNA gyrase subunit A	Mle GyrA	Mycobacterium species KMS
Msp-MCS GyrA	Theo.	DNA gyrase subunit A	Mle GyrA	Mycobacterium species MCS
Mvan GyrA	Theo.	DNA gyrase subunit A	Mle GyrA	Mycobacterium vanbaalenii PYR-1
Mxe GyrA	Exp.	DNA gyrase subunit A	Mle GyrA	Mycobacterium xenopi

Helicase (helicase-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Maeo-N3 Helicase	Theo.	DEAD/DEAH box helicase domain protein	Mja Helicase	Methanococcus aeolicus Nankai-3
Mja Helicase	Theo.	Putative SKI2-family helicase.	Mja Helicase	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Tko Helicase	Theo.	RNA helicase Ski2 homolog	Mja Helicase	Thermococcus kodakaraensis KOD1

Helicase (helicase-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mex Helicase	Theo.	DEAD/DEAH box Helicase	Ssp DnaX	Methylobacterium extorquens AM1
Spl DnaX	Theo.	DNA polymerase III gamma and tau subunits	Ssp DnaX	Spirulina platensis, strain C1
Ssp DnaX	Exp.	DNA pol III Tau-subunit	Ssp DnaX	Synechocystis species, strain PCC6803

Helicase- Primase (primase-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
ShP-Sfv-2a-2457T-n Primase	Theo.	DNA primase, Helicase	ShP-Sfv-5 Primase	Shigella flexneri 2a str. 2457T
ShP-Sfv-2a-301-n Primase	Theo.	DNA primase, Helicase	ShP-Sfv-5 Primase	Shigella flexneri 2a str. 301
ShP-Sfv-5 Primase	Theo.	DNA primase, Helicase	ShP-Sfv-5 Primase	Shigella flexneri 5 str. 8401

IF2, Translation initiation factor (IF2-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Bde-JEL423 eIF-5B	Theo.	Eukaryotic translation initiation factor 5B	Mja IF2	Batrachochytrium dendrobatidis JEL423
Mja IF2	Theo.	Translation initiation factor	Mja IF2	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Mka EF2	Theo.	Translation elongation/release factor (GTPase)	Mja IF2	Methanopyrus kandleri AV19
Pab IF2	Theo.	Translation initiation factor	Mja IF2	Pyrococcus abyssi
Pfu IF2	Theo.	Translation initiation factor	Mja IF2	Pyrococcus furiosus
Pho IF2	Theo.	Translation initiation factor	Mja IF2	Pyrococcus horikoshii OT3
Tko IF2	Theo.	Translation initiation factor	Mja IF2	Thermococcus kodakaraensis KOD1

KlbA (klbA-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mja KlbA	Exp.	KlbA, kilB operon ORF A	Mja KlbA	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Pab KlbA	Theo.	KlbA, kilB operon ORF A	Mja KlbA	Pyrococcus abyssi
Pfu KlbA	Theo.	KlbA, kilB operon ORF A	Mja KlbA	Pyrococcus furiosus
Pho KlbA	Theo.	KlbA, kilB operon ORF A	Mja KlbA	Pyrococcus horikoshii OT3
Tko KlbA	Theo.	KlbA,type II/IV secretion system ATPase	Mja KlbA	Thermococcus kodakaraensis KOD1

Large helicase related protein (LHR-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Pho LHR	Theo.	Large helicase related protein	Pho LHR	Pyrococcus horikoshii OT3
Tko LHR	Theo.	Large helicase related protein	Pho LHR	Thermococcus kodakaraensis KOD1

Lon, ATP-dependent protease LA (lon-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Pab Lon	Theo.	ATP-dependent protease LA	Pho Lon	Pyrococcus abyssi
Pfu Lon	Theo.	ATP-dependent protease LA	Pho Lon	Pyrococcus furiosus
Pho Lon	Theo.	ATP-dependent protease LA	Pho Lon	Pyrococcus horikoshii OT3

Mja rPol A'' (rPol A''-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hwa rPol A''	Theo.	DNA-directed RNA polymerase subunit A''	Mja rPol A''	Haloquadratum walsbyi DSM 16790
Mja rPol A''	Theo.	DNA-directed RNA polymerase subunit A''	Mja rPol A''	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Nph rPol A''	Theo.	DNA-directed RNA polymerase subunit A''	Mja rPol A''	Natronomonas pharaonis DSM 2160

MP-Be gp51 (MP-Be_gp51-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
MP-Be gp51	Theo.	gp51	Mbe gp51	Mycobacteriophage Bethlehem
MP-U2 gp50	Theo.	gp50	Mbe gp51	Mycobacteriophage U2

MupF (mupF-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
MP-Aaphi23 MupF	Theo.	Putative minor head protein,P32,traN-related protein	Mca MupF	Bacteriophage Aaphi23
Mca MupF	Theo.	Prophage MuMc02, F protein	Mca MupF	Methylococcus capsulatus Bath, prophage MuMc02

Phosphoenolpyruvate synthase (PEPsyn-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Cwa PEP	Theo.	Phosphoenolpyruvate synthase	Mja PEP	Crocosphaera watsonii WH 8501 (Synechocystis sp. WH 8501)
Mja PEP	Exp.	Phosphoenolpyruvate synthase	Mja PEP	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)

PRP8, pre-mRNA splicing factor (PRP8-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Abr PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Aspergillus brevipes FRR2439
Aca PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Ajellomyces capsulatus (anamorph: Histoplasma capsulatum)
Afu-Af293 PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Aspergillus fumigatus var. ellipticus, strain Af293
Afu-FRR0163 PRP8	Exp.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Aspergillus fumigatus strain FRR0163
Ani-FGSCA4 PRP8	Exp.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Aspergillus nidulans FGSC A
Avi PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Aspergillus viridinutans strain FRR0577
Bci PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Botrytis cinerea (teleomorph of Botryotinia fuckeliana B05.10)
Bde-JEL423 PRP8-2	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Batrachochytrium dendrobatidis JEL423
Cba-WM02.98 PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Cryptococcus bacillisporus strain WM02.98 (aka Cryptococcus neoformans gattii)
Cba-WM728 PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Cryptococcus bacillisporus strain WM728
Cga PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Cryptococcus gattii (aka Cryptococcus bacillisporus)
Cla PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Cryptococcus laurentii strain CBS139
Cne-A PRP8 (Fne-A PRP8)	Exp.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Filobasidiella neoformans (Cryptococcus neoformans) Serotype A, PHLS_8104
Cne-AD PRP8 (Fne-AD PRP8)	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Cryptococcus neoformans (Filobasidiella neoformans), Serotype AD, CBS132).
Cne-JEC21 PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Cryptococcus neoformans var. neoformans JEC21
Eni PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Emericella nidulans R20 (anamorph: Aspergillus nidulans)
Eni-FGSCA4 PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Emericella nidulans (anamorph: Aspergillus nidulans) FGSC A4
Hca PRP8	Exp.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Histoplasma capsulatum (anamorph: Ajellomyces capsulatus)
Nau PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Neosartorya aurata NRRL 4378
Nfi PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Neosartorya fischeri
Ngl-FR2163 PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Neosartorya glabra FRR2163
Ngl-FRR1833 PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Neosartorya glabra FRR1833
Nqu PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Neosartorya quadricincta, strain NRRL 4175
Nspi PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Neosartorya spinosa FRR4595
Pbl PRP8-a	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Phycomyces blakesleeanus
Pbl PRP8-b	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Phycomyces blakesleeanus
Pbr PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Paracoccidioides brasiliensis Pb18
Pch PRP8	Exp.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Penicillium chrysogenum
Pex PRP8	Exp.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Penicillium expansum
Ptr PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Pyrenophora tritici-repentis Pt-1C-BF
Pvu PRP8	Exp.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Penicillium vulpinum (formerly P. claviforme)
Ure PRP8	Theo.	PRP8, pre-mRNA splicing factor	Cne-AD PRP8	Uncinocarpus reesii

r-Gyr and TopA conserved topoisomerase domain (top-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mja r-Gyr	Theo.	Reverse gyrase	Mja r-Gyr	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Pfu TopA	Theo.	DNA topoisomerase I	Mja r-Gyr	Pyrococcus furiosus
Pho r-Gyr	Theo.	Reverse gyrase	Mja r-Gyr	Pyrococcus horikoshii OT3
Tko TopA	Theo.	DNA topoisomerase I	Mja r-Gyr	Thermococcus kodakaraensis KOD1
Tko r-Gyr	Theo.	Reverse gyrase	Mja r-Gyr	Thermococcus kodakaraensis KOD1

RecA (recA-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mbo RecA	Theo.	RecA	Mtu-H37Rv RecA	Mycobacterium bovis subsp. bovis AF2122/97
Mtu-H37Rv RecA	Exp.	RecA	Mtu-H37Rv RecA	Mycobacterium tuberculosis H37Rv,Also CDC1551
Mtu-So93 RecA	Exp.	RecA	Mtu-H37Rv RecA	Mycobacterium tuberculosis So93/sub_species="Canetti"

RecA (recA-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mch RecA	Theo.	RecA	Mle RecA	Mycobacterium chitae
Mfa RecA	Theo.	RecA	Mle RecA	Mycobacterium fallax
Mfl RecA	Exp.	RecA	Mle RecA	Mycobacterium flavescens Fla0
Mfl-ATCC14474 RecA	Theo.	RecA	Mle RecA	Mycobacterium flavescens, ATCC14474
Mga RecA	Theo.	RecA	Mle RecA	Mycobacterium gastri
Mle RecA	Exp.	RecA	Mle RecA	Mycobacterium leprae, strain TN
Msh RecA	Theo.	RecA	Mle RecA	Mycobacterium shimodei
Mthe RecA	Theo.	RecA	Mle RecA	Mycobacterium thermoresistibile
Tfus RecA-2	Theo.	RecA	Mle RecA	Thermobifida fusca YX

RecA (recA-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Pho RadA	Theo.	RadA DNA repair protein	Pho RadA	Pyrococcus horikoshii OT3
Tfus RecA-1	Theo.	RecA	Pho RadA	Thermobifida fusca YX
Tko RadA	Theo.	RadA/Rad51 recombinase	Pho RadA	Thermococcus kodakaraensis KOD1

Replication factor C (RFC-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hwa RCF	Theo.	Replication factor C	Mja RFC-1	Haloquadratum walsbyi DSM 16790
Mja RFC-1	Theo.	Replication factor C	Mja RFC-1	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Pab RFC-1	Theo.	Replication factor C	Mja RFC-1	Pyrococcus abyssi
Pfu RFC	Theo.	Replication factor C	Mja RFC-1	Pyrococcus furiosus
Pho RFC	Theo.	Replication factor C	Mja RFC-1	Pyrococcus horikoshii OT3
Tko RFC	Theo.	Replication factor C	Mja RFC-1	Thermococcus kodakaraensis KOD1

Replication factor C (RFC-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mja RFC-2	Theo.	Replication factor C	Mja RFC-2	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Mka RFC	Theo.	Replication factor C	Mja RFC-2	Methanopyrus kandleri AV19

Replication factor C (RFC-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mja RFC-3	Theo.	Replication factor C	Mja RFC-3	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Pab RFC-2	Theo.	Replication factor C	Mja RFC-3	Pyrococcus abyssi

Ribonucleoside Triphosphate Reductase (RIR1-d insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Nsp-PCC7120 RIR1	Exp.	Ribonucleoside Triphosphate Reductase, Class II	Nsp-PCC7120 RIR1	Nostoc species PCC7120, (Anabaena sp. PCC7120)
Ter RIR1-1	Exp.	Ribonucleoside Triphosphate Reductase, Class II	Nsp-PCC7120 RIR1	Trichodesmium erythraeum IMS101

Ribonucleoside-diphosphate reductase (RIR1-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Pab RIR1-1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-1	Pyrococcus abyssi
Pfu RIR1-1	Exp.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-1	Pyrococcus furiosus
Tko RIR1-1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-1	Thermococcus kodakaraensis KOD1

Ribonucleoside-diphosphate reductase (RIR1-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Aave RIR	Theo.	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, RNR, class I_like	Pfu RIR1-2	Acidovorax avenae subsp. citrulli AAC00-1
Aeh RIR1	Theo.	Ribonucleoside reductase, RNR, class I_like	Pfu RIR1-2	Alkalilimnicola ehrlichei MLHE-1
Cag RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Chlorochromatium aggregatum
Cch RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Chlorobium chlorochromatii CaD3
Chy RIR1	Exp.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Carboxydothermus hydrogenoformans Z-2901
Dha-DCB2 RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Desulfitobacterium hafniense DCB-2
Dha-Y51 RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit, RNR, class I_like	Pfu RIR1-2	Desulfitobacterium hafniense Y51
Dra RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Deinococcus radiodurans R1,TIGR strain
Fac-Fer1 RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Ferroplasma acidarmanus, taxon:97393 and taxon 261390
Fac-TypeI RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Ferroplasma acidarmanus type I,
Gvi RIR1-2	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Gloeobacter violaceus, PCC 7421
Mca RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Methylococcus capsulatus Bath
Mth RIR1	Exp.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Methanothermobacter thermautotrophicus (Methanobacterium thermoautotrophicum)
Pab RIR1-3	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Pyrococcus abyssi
Par RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Pyrobaculum arsenaticum DSM 13514
Pfu RIR1-2	Exp.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Pyrococcus furiosus
Pho RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Pyrococcus horikoshii OT3
Plut RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Pelodictyon luteolum DSM 273
Pna RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit, RNR, class I_like	Pfu RIR1-2	Polaromonas naphthalenivorans CJ2
Posp-JS666 RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Polaromonas species JS666
Rsp RIR1	Theo.	Ribonucleoside reductase, RNR, class I_like	Pfu RIR1-2	Roseovarius species 217
Sel-PC6301 RIR1	Theo.	Ribonucleoside Triphosphate Reductase	Pfu RIR1-2	Synechococcus elongatus PCC 6301
Sel-PC7942 RIR1	Theo.	Ribonucleoside Triphosphate Reductase	Pfu RIR1-2	Synechococcus elongatus PC7942
Ssp-JA2 RIR1	Theo.	Ribonucleoside Triphosphate Reductase, RNR, class II	Pfu RIR1-2	Synechococcus species JA-2-3B'a(2-13)
Ssp-JA3 RIR1	Theo.	Ribonucleoside Triphosphate Reductase, RNR, class II	Pfu RIR1-2	Synechococcus species JA-3-3Ab
Ter RIR1-2	Exp.	Ribonucleoside Triphosphate Reductase, Class II	Pfu RIR1-2	Trichodesmium erythraeum IMS101
Tko RIR1-2	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Thermococcus kodakaraensis KOD1
Tth-HB27 RIR1-2	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Thermus thermophilus HB27
Tth-HB8 RIR1-2	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	Thermus thermophilus HB8
Unc-ERS RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Pfu RIR1-2	uncultured archaeon GZfos9C4

Ribonucleoside-diphosphate reductase (RIR1-e insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Gvi RIR1-1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Gvi RIR1-1	Gloeobacter violaceus, PCC 7421
Tth-HB27 RIR1-1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Gvi RIR1-1	Thermus thermophilus HB27
Tth-HB8 RIR1-1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Gvi RIR1-1	Thermus thermophilus HB8

Ribonucleoside-diphosphate reductase (RIR1-g insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Hwa RIR1-2	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Ter RIR1-4	Haloquadratum walsbyi DSM 16790
Ter RIR1-4	Exp.	Ribonucleoside Triphosphate Reductase, Class II	Ter RIR1-4	Trichodesmium erythraeum IMS101

Ribonucleoside-diphosphate reductase (RIR1-i insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
BsuP-M1918 RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	CIV RIR1	B.subtilis M1918 (prophage)
BsuP-SPBc2 RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	CIV RIR1	B.subtilis strain 168 Sp beta c2 prophage
CIV RIR1	Exp.	Ribonucleoside- diphosphate reductase, alpha subunit	CIV RIR1	Chilo iridescent virus
CV-NY2A RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	CIV RIR1	Chlorella virus NY2A infects Chlorella NC64A, which infects Paramecium bursaria
CZIV RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit, RNR, class I	CIV RIR1	Costelytra zealandica iridescent virus
Cwa RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	CIV RIR1	Crocosphaera watsonii WH 8501 (Synechocystis sp. WH 8501)
IIV6 RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	CIV RIR1	Invertebrate iridescent virus 6
Sep RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	CIV RIR1	Staphylococcus epidermidis RP62A
Sru RIR1	Theo.	Ribonucleoside-diphosphate reductase, alpha chain, RNR, class I	CIV RIR1	Salinibacter ruber DSM 13855
WIV RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit, RNR, class I	CIV RIR1	Wiseana iridescent virus

Ribonucleoside-diphosphate reductase (RIR1-j insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Ace RIR1	Theo.	Ribonucleoside diphosphate reductase, RNR, class I_like	Nfa RIR1	Acidothermus cellulolyticus 11B
Fsp-CcI3 RIR1	Theo.	Ribonucleoside diphosphate reductase, B12-dependent, RNR, class I_like	Nfa RIR1	Frankia species CcI3
Nfa RIR1	Theo.	Ribonucleoside- diphosphate reductase, alpha subunit	Nfa RIR1	Nocardia farcinica IFM 10152

Ribonucleotide reductase, Anaerobic (RNR-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Mja RNR-2	Theo.	Ribonucleotide reductase, Anaerobic, RNR, class III	Mja RNR-2	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Unc-ERS RNR	Theo.	Ribonucleotide reductase, Anaerobic	Mja RNR-2	uncultured archaeon GZfos10C7

Ribonucleotide reductase, Anaerobic (RNR-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
CbP-C-St RNR	Theo.	Ribonucleotide reductase, Anaerobic, RNR, class III	CbP-C-St RNR	Clostridium botulinum phage C-St
CbP-D RNR	Theo.	Ribonucleotide reductase, Anaerobic,large subunit, RNR, class III	CbP-C-St RNR	Clostridium botulinum phage D

RNA polymerase II, RPB2 (RPB2-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Cst RPB2	Theo.	DNA-directed RNA polymerase II, second largest subunit	Cst RPB2	Coelomomyces stegomyiae
Sas RPB2	Theo.	DNA-directed RNA polymerase II, second largest subunit	Cst RPB2	Spiromyces aspiralis NRRL 22631
She RPB2 (RpoB)	Theo.	DNA-directed RNA polymerase beta subunit	Cst RPB2	Stigeoclonium helveticum, strain UTEX 441

RNA polymerase II, RPB2 (RPB2-c insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Bde-JEL197 RPB2	Theo.	DNA-directed RNA polymerase II, second largest subunit	Bde-JEL197 RPB2	Batrachochytrium dendrobatidis JEL197
Bde-JEL423 RPC2	Theo.	DNA-directed RNA polymerase III,second largest subunit	Bde-JEL197 RPB2	Batrachochytrium dendrobatidis JEL423

RNA terminal phosphate cyclase operon orfB (rtcB-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Maeo-N3 RtcB	Theo.	Protein of unknown function UPF0027	Mja RtcB	Methanococcus aeolicus Nankai-3
Mja RtcB (Mja Hyp-2)	Theo.	RNA terminal phosphate cyclase operon orfB	Mja RtcB	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)
Mka RtcB	Theo.	RNA terminal phosphate cyclase operon orfB	Mja RtcB	Methanopyrus kandleri AV19
Pab RtcB (Pab Hyp-2)	Theo.	RNA terminal phosphate cyclase operon orfB	Mja RtcB	Pyrococcus abyssi
Pfu RtcB (Pfu Hyp-2)	Theo.	RNA terminal phosphate cyclase operon orfB	Mja RtcB	Pyrococcus furiosus
Pho RtcB (Pho Hyp-2)	Theo.	RNA terminal phosphate cyclase operon orfB	Mja RtcB	Pyrococcus horikoshii OT3

Snf2 helicase/Rad54 -related protein, (snf2-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Dra Snf2-c	Theo.	SNF2/Rad54 helicase	Dra Snf2	Deinococcus radiodurans R1, TIGR strain
Dra Snf2-n	Theo.	SNF2/Rad54 helicase	Dra Snf2	Deinococcus radiodurans R1, TIGR strain
Dra-ATCC13939 Snf2	Exp.	SNF2/Rad54 helicase	Dra Snf2	Deinococcus radiodurans R1, ATCC13939/Brooks & Murray strain
Sav Helicase	Theo.	ATP-dependent DNA helicase	Dra Snf2	Streptomyces avermitilis MA-4680
Ter Snf2	Theo.	SNF2/Rad54 helicase	Dra Snf2	Trichodesmium erythraeum IMS101

SufB FeS assembly protein, formerly Pps1 (SufB-b inseriton site)
Intein Name	Class	Extein	Prototype Allele	Organism
Fac-Fer1 SufB (Fac Pps1)	Theo.	FeS assembly protein SufB, formerly Pps1	Mtu SufB	Ferroplasma acidarmanus
Fac-typeI SufB (Fac Pps1)	Theo.	FeS assembly protein SufB, formerly Pps1	Mtu SufB	Ferroplasma acidarmanus
Mbo Pps1	Theo.	FeS assembly protein SufB, formerly Pps1	Mtu SufB	Mycobacterium bovis subsp. bovis AF2122/97
Mbo SufB (Mbo Pps1)	Theo.	FeS assembly protein SufB, formerly Pps1	Mtu SufB	Mycobacterium bovis subsp. bovis AF2122/97
Mtu SufB (Mtu Pps1)	Theo.	FeS assembly protein SufB, formerly Pps1	Mtu SufB	Mycobacterium tuberculosis strains H37Rv & CDC1551

Threonyl-tRNA synthetase (thrRS-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Cpa ThrRS	Theo.	Threonyl-tRNA synthetase	Ctr ThrRS	Candida parapsilosis, strain CLIB214
Ctr ThrRS	Theo.	Threonyl-tRNA synthetase	Ctr ThrRS	Candida tropicalis ATCC750

UDP-glucose 6-dehydrogenase (UDP_GD-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Maeo-N3 UDP GP	Theo.	UDP-glucose 6-dehydrogenase	Mja UDP GD	Methanococcus aeolicus Nankai-3
Mja UDP GD	Theo.	UDP-glucose 6-dehydrogenase	Mja UDP GD	Methanococcus jannaschii (Methanocaldococcus jannaschii DSM 2661)

Vacuolar ATPase / H+-transporting ATP synthase (VMA-a insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Cgl VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Candida glabrata
Ctr VMA	Exp.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Candida tropicalis (nucleus)
Dhan VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Debaryomyces hansenii CBS767
Kex-CBS379 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Kazachstania exigua, formerly Saccharomyces exiguus, strain CBS379
Kla-CBS683 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Kluyveromyces lactis, strain CBS683
Kla-IFO1267 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Kluyveromyces lactis IFO1267
Kla-NRRLY1140 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Kluyveromyces lactis NRRL Y-1140
Lel VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Lodderomyces elongisporus
Pst VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Pichia stipitis CBS 6054, taxon:322104
Sca-CBS4309 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces castellii, strain CBS4309
Sca-IFO1992 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces castellii, strain IFO1992
Scar VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces cariocanus, strain="UFRJ 50791
Sce VMA	Exp.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces cerevisiae (nucleus)
Sce-DH1-1A VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces cerevisiae strain DH1-1A
Sce-OUT7091 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces cerevisiae OUT7091
Sce-OUT7112 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces cerevisiae OUT7112
Sda VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces dairenensis, strain CBS 421
Sex-IFO1128 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces exiguus, strain="IFO1128"
Sja VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Schizosaccharomyces japonicus yFS275
Spa VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces pastorianus IFO11023
Sun VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Saccharomyces unisporus, strain CBS 398
Tgl VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Torulaspora globosa, strain CBS 764
Tpr VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Torulaspora pretoriensis, strain CBS 5080
Vpo VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Vanderwaltozyma polyspora, formerly Kluyveromyces polysporus, strain CBS 2163
Zba VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Zygosaccharomyces bailii, strain CBS 685
Zbi VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Zygosaccharomyces bisporus, strain CBS 702
Zro VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Sce VMA	Zygosaccharomyces rouxii, strain CBS 688

Vacuolar ATPase / H+-transporting ATP synthase (VMA-b insertion site)
Intein Name	Class	Extein	Prototype Allele	Organism
Pab VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Pho VMA	Pyrococcus abyssi
Pfu VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Pho VMA	Pyrococcus furiosus
Pho VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Pho VMA	Pyrococcus horikoshii OT3
Pto VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Pho VMA	Picrophilus torridus, DSM 9790
Tac-ATCC25905 VMA	Exp.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Pho VMA	Thermoplasma acidophilum, ATCC 25905
Tac-DSM1728 VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Pho VMA	Thermoplasma acidophilum, DSM1728
Tvo VMA	Theo.	Vacuolar ATPase (H+-transporting ATP synthase), subunit A	Pho VMA	Thermoplasma volcanium GSS1

Last database update: 04/02/08

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